AMYGDALIN (LAETRILE) B-17
MONOGRAPHIC SUMMARY
Edited by Dr. Jose Ernesto Contreras Pulido
Clinical Research of the Hospital Ernesto Contreras In Collaboration
with: KEM S.A. Laboratories and Hospital Oasis
In spite of the great advances in the diagnosis and treatment of malignant tumors, cancer continues be one of the principal causes of death in the highly industrialized countries. It is calculated that one out of four persons will eventually die from some form of cancer. Since it is true that surgery and radiotherapy are capable of curing some patients with localized tumors and that chemotherapy has achieved cures in some ten types of malignant tumors, the general mortality rate from cancer has not improved substantially in the last 25 years and nearly 60 percent of the patients, upon being diagnosed, find that their disease is so widespread that the chemotherapy drugs currently being used, due to their high toxicity, cannot be given in dosages sufficient to destroy the large tumoral mass present in patients. Many cannot be exposed to therapy, surgery or radiotherapy because of the undesirable effects. There are several types of tumors for which there is no effective treatment yet known.
All this justifies, and even makes imperative, the search for new substances with anti-tumor effect and ideally, with little or no toxicity in therapeutic doses. In the last ten years, several vegetable and hormonal substances have been discovered with such characteristics and, therefore, many patients who formerly could not be benefited or alleviated medicinally may now be exposed to useful , antineoplastic treatments.
KEM S.A. Laboratories, with great satisfaction, is able to present a vegetable agent whose anti-tumor action was known empirically for many years, but in the last twenty years has been scientifically proven, primarily through the clinical studies directed by Dr. Ernesto Contreras Rodriguez and carried out in the Centro Medico y Hospital Del Mar at Playas de Tijuana, B.C.N. Mexico.
This anti-tumor agent is AMYGDALIN (commonly known as Laetrile).
AMYGDALIN is a natural substance that can be found in a variety of species in the vegetable kingdom. The greatest concentration is found in the seeds of the rosaceous fruits, such as the apricot pits and other biter nuts. There are many seeds, cereals and vegetables that contain minimal quantities of Amygdalin and form part of our daily diet.
Various documents from the oldest civilizations such as Egypt at the time of the Pharaohs and from China 2,500 years before Christ mention the therapeutic use of derivatives of bitter almonds. Egyptian papyri from 5,000 years ago mention the use of "aqua amigdalorum" for the treatment of some tumors of the skin. The Greeks and Romans also attributed therapeutic properties to that extract in low doses. But the systematized study of AMYGDALIN really did not begin until the first half of the past century, when the chemist Bohn discovered in 1802 that during the distillation of the water from bitter almonds hydrocyanic acid was released.
Soon many researchers became interested in analyzing this extract and so Robiquet and Boutron isolated, for the first time, a white crystalline substance which they called AMYGDALIN (from amygdala = almond)
Leiberg and Wholler in 1937 isolated an enzymatic compound from sweet almonds, also present in the biter ones, which they called emulsin. They later reported that emulsin broke AMYGDALIN down into three compounds: glucose, hydrocyanic acid, and benzaldehyde.
Studies from that time, performed by several authors, can summarize the declaration made by Otto Jacobsen in his book "Die Glucoside" in 1887: "AMYGDALIN is not toxic," and gives 99 references from studies made within the 20 years prior to his publication.
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